A Palestinian woman walks near the controversial Israeli barrier as she crosses a checkpoint in the West Bank city of Bethlehem September 5, 2008, on her way to the al-Aqsa mosque in Jerusalem on the first Friday of the Muslim holy month of Ramadan.
(Yannis Behrakis/Reuters)This Aug. 26, 2008 file photo shows Sen. Hillary Rodham Clinton, D-N.Y., as she waves at the crowed after her daughter, Chelsea Clinton, introduced her at the Democratic National Convention in Denver. One of the most intriguing questions of Republican vice presidential candidate Sarah Palin's arrival on the national scene has been what impact it'll have on women voters — especially those who supported Clinton.
(AP Photo/Charlie Neibergall, FILE)Sandy Goodman was deeply disappointed when Hillary Rodham Clinton didn't get the Democratic nomination, then again when she was bypassed for the VP spot. So Goodman, a longtime Florida Democrat, flirted with thoughts of shunning Barack Obama, and perhaps even voting Republican.
Then John McCain picked Sarah Palin as his running mate, and suddenly things became clear to Goodman: The Republicans had no place for her.
"Boy, you are sure not talking to ME!" Goodman, 61, says she thought when she heard Palin's views on issues like abortion rights. Now, Goodman is volunteering for Obama.
But then there's Chrissie Peters. The 37-year-old librarian from Bristol, Tenn. has always voted Democratic and supported Clinton. She assumed she'd vote for Obama — until she saw Palin speak. Now she's voting Republican.
"She was so down-to-earth, a regular person," says Peters. "She hasn't been in politics her whole life, so she isn't jaded or tainted. And I love that she's a mom. Yes, I disagree with some of her positions, but that's what this country is about."
One of the most intriguing questions about the Alaska governor's sudden arrival on the national scene has been what impact it'll have on women voters — especially those who supported Clinton.
Palin made an overture to those voters in her first speech after being chosen by McCain.
Will the pitch work?
Evidence so far shows that Palin is not drawing a lot of support from voters outside the Republican base.
An ABC News poll released Friday found the selection of Palin makes people likelier to vote for McCain by just 6 percentage points — half the 12-point margin by which Sen. Joe Biden makes them more likely to support Obama.
And as for Clinton supporters, eight in 10 said they'd vote for Obama in November, according to a Gallup Poll conducted last weekend after McCain announced his selection of Palin.
Diane Mantouvalos, for one, thinks the numbers are behind the tide.
"We've always been a few weeks ahead of the polls," says the founder of the JustSayNoDeal Web site, a clearinghouse for groups of disaffected Clinton supporters seeking to punish the Democratic Party and Obama for what they see as inexcusable treatment of Clinton.
Mantouvalos hasn't decided whom she'll support in November. But she believes many former Clinton supporters will end up voting for McCain. And she thinks Palin will help make that happen.
"I was there," Mantouvalos says of Palin's convention speech. "I was blown away. She seemed so confident in her own skin."
And what about all the issues on which Palin differs so sharply from Clinton? "Principle trumps issues for this group," she says of her and others like her.
To Gloria Steinem, the nation's most recognizable feminist, that logic is mystifying.
"Selecting Sarah Palin ... is no way to attract most women, including die-hard Clinton supporters," Steinem wrote this week in the Los Angeles Times, arguing that McCain's running mate is seriously underqualified. "Palin shares nothing but a chromosome with Clinton."
In an e-mail to The Associated Press, Steinem added: "I have yet to meet one single human being who was for Hillary and is now for McCain, with or without Palin, but some must exist somewhere."
Historically, women vote on the issues, not by the gender of the candidate, and since 1980 they've trended Democratic for that reason, says Debbie Walsh, director of the Center for American Women and Politics at Rutgers University.
"I wouldn't expect that the McCain-Palin ticket will pull in Clinton supporters," says Walsh. "They were supporting her on the issues. Her gender just added to the appeal."
Whatever appeal gender has for female voters, Obama's campaign is not about to let McCain corner the market. Clinton herself, along with Arizona Gov. Janet Napolitano and Kansas Gov. Kathleen Sebelius, all are scheduled to campaign for Obama in the coming weeks, particularly where they can vouch for Obama to large female audiences
The Washington group EMILY's List, which backs female candidates who support abortion rights, says its own polling shows that a majority of Clinton supporters — 55 percent — say Palin's presence on the ticket makes them even less likely to vote McCain. Only 9 percent say it makes that more likely.
"There really couldn't be more of a distance between Sarah Palin and Hillary Clinton on the issues and the agenda that Clinton fought so passionately for," the group's executive director, Ellen Moran, said in an interview. "The more (Clinton supporters) are learning about Palin, the more they are coming to the Obama-Biden ticket."
That's not the case for self-described "Clinton die-hard" Amy Goldman. The consultant from Edgewater, N.J. says she'd been leaning toward McCain for a while, but his pick of Palin sealed the deal.
"His pick goes outside the box," said Goldman, 52, who like Mantouvalos is involved in the Internet-based efforts to challenge the Democratic party. "I'm not being bitter by voting this way. I really think they're a great ticket."
Liz Hunter won't go that far. The 25-year-old Clinton fan is deeply conflicted. She's not ready to support Obama, but doesn't think she could seriously vote Republican. She read Palin's speech online, so she could pay attention to the details. "Sometimes on TV, you get caught up with all the applause," she says.
"I really respect the fact that she has five children and a career, and keeps her family strong," said Hunter. But at the same time, "I just don't think I could go over to that side." The debates will decide it, she says.
For Goodman, the Florida voter who's shifted to Obama, there will be no such indecision. She'll work to convince fellow Clintonites that they shouldn't be swayed by the woman on the Republican ticket.
"I was insulted when she referred to Hillary and the 18 million cracks in the ceiling," Goodman says, referring to Clinton's line that her primary votes put that many cracks in the glass ceiling that has held women back. "I don't believe Hillary was making those 18 million cracks for Sarah Palin."
Article: HERE
Judy Garland's Arabian ruby slippers, one of five pairs designed by Adrian Greenberg of MGM studios and worn by Garland for test and wardrobe shots in the 1939 film 'The Wizard of Oz, ' are displayed at Saks Fifth Avenue in New York, Thursday, Sept. 4, 2008, part of an exhibit of ruby shoes created along the gemmed red slippers theme by well-known designers. Considered the most rare of all the ruby slippers used while making the film, the pair shown are owned by actress Debbie Reynolds.
(AP Photo/Kathy Willens)Judy Garland's Arabian ruby slippers, one of five pairs designed by Adrian Greenberg of MGM studios and worn by Garland for test and wardrobe shots in the 1939 film 'The Wizard of Oz, ' are displayed at Saks Fifth Avenue in New York, Thursday, Sept. 4, 2008, part of an exhibit of ruby shoes created along the gemmed red slippers theme by well-known designers. Considered the most rare of all the ruby slippers used while making the film, the pair shown are owned by actress Debbie Reynolds.
(AP Photo/Kathy Willens)Judy Garland's Arabian ruby slippers, one of five pairs believed designed by Adrian Greenberg of MGM studios and worn by Garland for test and wardrobe shots in the 1939 film 'The Wizard of Oz, ' are displayed at Saks Fifth Avenue in New York, Thursday, Sept. 4, 2008, part of an exhibit of ruby shoes created along the gemmed red slippers theme by well-known designers. The shoes, considered the most rare of all the ruby slippers used while making the film, are owned by Debbie Reynolds.
(AP Photo/Kathy Willens)Vincent Beggs, an independent curator for Warner Brothers Studios, adjusts Judy Garland's Arabian ruby slippers, one of five pairs believed designed by Adrian Greenberg of MGM studios and believed worn by Garland for test and wardrobe shots in the 1939 film 'The Wizard of Oz. ' Beggs was setting the shoes up for a showing at Saks Fifth Avenue in New York, Thursday, Sept. 4, 2008. The shoes are part of an exhibit of ruby shoes created along the gemmed red slippers theme by well-known designers. The shoes, considered the most rare of all the ruby slippers used while making the film, are owned by Debbie Reynolds.
(AP Photo/Kathy Willens)Oscar de la Renta ruby shoes are displayed at Saks Fifth Avenue in New York, Thursday, Sept. 4, 2008, part of an exhibit of ruby slippers created along the gemmed red slippers theme by well-known designers commemorating the 70th anniversary of the 1939 film, 'The Wizard of Oz.'
(AP Photo/Kathy Willens)Ruby shoes designed by Stuart Weitzman are displayed at Saks Fifth Avenue in New York, Thursday, Sept. 4, 2008, part of an exhibit of ruby shoes created along the gemmed red slippers theme by well-known designers. The exhibit commemorates the 70th anniversary of the 1939 film, 'The Wizard of Oz. '
(AP Photo/Kathy Willens)Abaete ruby shoes are displayed at Saks Fifth Avenue in New York, Thursday, Sept. 4, 2008, part of an exhibit of ruby slippers created by well-known designers commemorating the 70th anniversary of the 1939 film, 'The Wizard of Oz.'
(AP Photo/Kathy Willens)Stephanie Thistle and Christina Rushing admire ruby shoes designed by Roger Vivier displayed at Saks Fifth Avenue in New York, Thursday, Sept. 4, 2008, part of an exhibit of ruby slippers created by well-known designers commemorating the 70th anniversary of the 1939 film, 'The Wizard of Oz.'
(AP Photo/Kathy Willens)Palestinian Muslim worshipers show their IDs as they stand in line waiting to cross at the Israeli army checkpoint at Kalandiya, between Ramallah and Jerusalem, Friday, Sep. 5, 2008. Around 90,000 Muslims congregated in Jerusalem for the first Friday prayers of the holy month of Ramadan, police spokesman Micky Rosenfeld said. He said 'thousands' of police were deployed around the city to 'prevent any disturbances.'
(AP Photo/Kevin Frayer)JERUSALEM – Israel allowed Palestinian security forces in the West Bank to receive a shipment of about 1,000 Kalashnikov rifles and tens of thousands of bullets in a step aimed at bolstering the moderate Palestinian government there, an Israeli defense official said Friday.
Shipments of this type remain sensitive for Israel because weapons provided to Palestinian security forces during peace talks in the 1990s were used against Israelis when those talks broke down in violence in 2000. But balancing those concerns are fears that if moderate forces are too weak they might lose control of the West Bank to Hamas, the hardline Islamic group that seized power in the Gaza Strip last year.
The weapons shipment reached the Palestinians through Jordan about one week ago, the Israeli official said. Israeli Prime Minister Ehud Olmert and Palestinian President Mahmoud Abbas arranged the transfer when they met August 31, he said.
The official spoke on condition of anonymity because he was not authorized to make the shipment public, though it seemed likely Israeli authorities wanted the information in the open.
Israel is under pressure to at least appear to be supporting Abbas as part of U.S.-sponsored peace negotiations. However, critics both at home and abroad say Israel has not carried out key confidence-building measures, such as halting settlement activity and dismantling roadblocks, that could help the negotiations succeed.
The Palestinians, for their part, have been criticized for not doing enough to crack down on militants — which is also seen as key to the talks' success.
Abbas adviser Nimr Hamad and Diab Ali, a West Bank security commander, denied knowledge of the weapons transfer.
Israel has approved similar shipments in the past, and is allowing Abbas' security forces to assume a larger role in some parts of the West Bank. But Israel's military maintains overall control of the West Bank and of its border crossings with Jordan, including the Allenby Bridge terminal where the weapons crossed into the territory, according to the Israeli official.
In current peace talks between Israel and Abbas' government, Israel is insisting that a future Palestinian state be demilitarized. The Palestinians are balking, and the issue is emerging as one of a number of sticking points in the negotiations, according to Palestinian officials close to the talks.
Also on Friday, around 90,000 Muslims congregated at the Al Aqsa Mosque compound in Jerusalem for the first communal prayers of the holy month of Ramadan, police spokesman Micky Rosenfeld said. He said "thousands" of police were deployed around the city to prevent any disturbances.
Citing security concerns, police restricted the entry of Palestinians, banning men under 45 and requiring many women to produce valid entry permits. In the past, some Friday services at the site — sacred to both Muslims and Jews — have ended in riots.
At one checkpoint north of Jerusalem, Palestinians threw stones at troops, who responded with tear gas and stun grenades. No injuries were reported.
Article: HERE
A Palestinian boy stands in line as he waits to cross a checkpoint on his way to Jerusalem during the first Friday of Ramadan, in Bethlehem, Friday, Sept. 5, 2008. Around 90,000 Muslims congregated in Jerusalem for the first Friday prayers of the holy month of Ramadan, police spokesman Micky Rosenfeld said. He said 'thousands' of police were deployed around the city to 'prevent any disturbances.'
(AP Photo/Tara Todras-Whitehill)Israeli border police officers let a Palestinian Muslim worshiper walk through as others wait to cross at the Israeli army checkpoint at Kalandiya, between Ramallah and Jerusalem, Friday, Sep. 5, 2008. Around 90,000 Muslims congregated in Jerusalem for the first Friday prayers of the holy month of Ramadan, police spokesman Micky Rosenfeld said. He said 'thousands' of police were deployed around the city to 'prevent any disturbances.'
(AP Photo/Nasser Ishtayeh)A Palestinian Muslim worshipper is backdropped by the Russian Orthodox Church as she prays during the first Friday prayers of the holy fasting month of Ramadan in the Al-Aqsa Mosque compound in Jerusalem's Old City, Friday, Sept. 5, 2008. Around 90,000 Muslims congregated in Jerusalem for the first Friday prayers of the holy month of Ramadan, police spokesman Micky Rosenfeld said. He said 'thousands' of police were deployed around the city to 'prevent any disturbances.'
(AP Photo/Muhammed Muheisen)
By HILLEL ITALIE, AP National Writer
25 mins ago
Robert Giroux, giant of publishing, dies
NEW YORK – Robert Giroux, a distinguished giant of 20th century publishing who guided and supported dozens of great writers from T.S. Eliot and Jack Kerouac to Bernard Malamud and Susan Sontag, died in his sleep early Friday morning. He was 94.
Giroux, who helped create one of the most notable publishing houses — Farrar, Straus & Giroux — had been in failing health for a couple of months and died at an assisted living facility in Tinton Falls, N.J., Jeff Seroy, a Farrar, Straus spokesman, said.
Known throughout the industry for his taste and discretion, he began in 1940 as an editor at Harcourt, Brace & Company and had so great a reputation that when he left in 1955 to join what was then Farrar, Straus, more than a dozen writers joined him, including Flannery O'Connor, Malamud and Eliot, a close friend.
"(W)hen I faced a difficult decision about my own career, his support and encouragement saw me through a crisis," Giroux later said of the poet.
Giroux joined Farrar as editor in chief and was made a full partner in 1964, his reserved demeanor in contrast to the company's boisterous founder and president, Roger Straus. Straus and Giroux thrived together even as they endlessly complained about each other, with Straus regarding Giroux as a snob, and Giroux looking upon Straus as more a businessman than a man of letters.
During Giroux's 60-year career, some of the world's most celebrated writers published works for FSG, including Nobel Prize winners Isaac Bashevis Singer, Derek Walcott, Nadine Gordimer and Seamus Heaney. Authors were known to turn down more money from competitors for the privilege of being signed on by Farrar, Straus.
"The single most important thing to happen to this company was the arrival of Bob Giroux," Straus, who died in 2004, once said.
Even after FSG sold controlling interest in 1994 to German publisher Verlagsgruppe Georg von Holtzbrinck, it retained the reputation as an upholder of old-fashioned standards, more attuned to lasting quality than to instant profit. Sometimes, it achieved both, with such works as Jonathan Franzen's "The Corrections," Jeffrey Eugenides' "Middlesex" and Marilynne Robinson's "Gilead."
Giroux was an author himself, writing "The Book Known as Q: A Consideration of Shakespeare's Sonnets." He also contributed introductions to "The Complete Stories of Flannery O'Connor" and to anthologies of Malamud, John Berryman and Elizabeth Bishop. But a planned memoir was never completed.
Able to work with relative freedom, Giroux was still a strong critic of contemporary publishing, which he believed had become too money-minded. "Editors used to be known by their authors," he observed in a 1981 lecture. "Now some of them are known by their restaurants."
In 1987, Giroux received a lifetime achievement award from the National Book Critics Circle for his "distinguished contribution to the enhancement of American literary and critical standards." In 2002, he received an honorary prize from the American Academy of Arts and Letters.
Giroux was married to Carmen de Arango in 1952. They divorced in 1969.
A native of New Jersey, Giroux was a star student at Columbia University, where his classmates included Berryman, Herman Wouk and Thomas Merton. In his mid-20s, he joined Harcourt, Brace, and was soon assigned Edmund Wilson's now-classic study on socialist thinkers, "To the Finland Station."
"Thus, at the start of my life as an editor, I experienced the rarest and most ideal situation: a manuscript needing few or no changes. This is what every editor, and author, really wants," Giroux later recalled.
But he eventually became "fed up" at Harcourt, "with textbooks dominating this admirable house." Giroux sought advice from Straus, a fellow Navy officer during World War II. Straus' suggestion: Come work for him.
"For me, the new firm was a breath of fresh air — no textbooks, interesting writers, and the editors could take chance," Giroux later wrote.
Among the debut novels he worked on were Malamud's "The Natural," Jack Kerouac's "The Town and the City" and O'Connor's "Wise Blood." Giroux also edited Susan Sontag, Robert Lowell and Hannah Arendt.
But Giroux did miss out at least twice. In the early 1950s, a young writer ("very tall, dark-haired, had a horse face") arrived unannounced to the Harcourt offices with a novel about a disenchanted prep school student. Giroux was immediately interested, but a Harcourt executive overruled him, saying the publisher's textbook department had read the book and passed on it, thus rejecting J.D. Salinger's "The Catcher in the Rye."
Around the same time, another young writer appeared at Harcourt, carrying what Giroux would remember as "rubbery sheets, ... teletype sheets pasted together." The author unfurled the scroll on the floor, revealing a story that ran more than 100 feet long, in a continuous paragraph.
When Giroux complained he couldn't possibly edit such a work, the writer called him a "crass idiot," rolled up his goods and hurried out.
So departed Kerouac and his manuscript for "On the Road."
Funeral plans were not immediately known.
Article: HERE
Jenny, a Western Lowland Gorilla and the world's oldest captive gorilla, celebrates her 55th birthday at the Dallas Zoo in a Thursday, May 8, 2008 file photo. Jenny has died at her home in the Dallas Zoo, a spokesman said Friday, Sept. 5, 2008.
(AP Photo/Tony Gutierrez, File)DALLAS – The oldest gorilla in captivity, a 55-year-old female named Jenny, has died at the Dallas Zoo — her home for more than half a century, a spokesman said Friday.
Zoo officials decided to euthanize Jenny on Thursday night because of an inoperable tumor in her stomach. Jenny had stopped eating and drinking recently, and tests showed she was unlikely to recover, spokesman Sean Greene said.
Jenny's keepers described her as very sweet though a little bossy.
"If she doesn't want to go out on a certain day, she doesn't," Todd Bowsher, curator of the zoo's Wilds of Africa exhibit, said in May, when the zoo held a birthday bash to celebrate Jenny's longevity. "But she really likes people."
The International Species Information System, which maintains records on animals at 700 institutions around the world, confirmed earlier this year that Jenny was the oldest gorilla in its database.
Jenny was born in the wild and was acquired by the zoo in 1957. She gave birth in 1965 to a female named Vicki, and officials aren't sure why she didn't conceive again. Vicki was sent to a Canadian zoo at age 5.
At the time of Jenny's death she was one of five gorillas at the Dallas Zoo.
Gorillas in the wild normally live to age 30 or 35, but they can survive years longer in a zoo, with veterinary care and protection from predators. Still, of the roughly 360 gorillas in North American zoos, only four were over 50 as of this spring.
Just last month, another gorilla at the zoo, 43-year-old Hercules, died after undergoing a medical procedure for spinal disease.
In 2004, Dallas police shot and killed a 13-year-old gorilla named Jabari at the zoo after it jumped over a wall, bit three people and snatched up a toddler by his teeth. The enclosure was remodeled and the city paid a fine to the U.S. Department of Agriculture.
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On the Net:
http://www.dallaszoo.com
Article: HERE
A quiver dated from Neolithic and found at the 2,756 metre-high Schnidejoch alpine pass, western Swiss Alps. So far, 300 objects dating as far back as the Neolithic or New Stone Age -- about 4,000 BC in Europe -- to the later Bronze and Iron Ages and the Medieval era have been found in the site's former icefields.
(AFP/HO)BERN (AFP) – Some 5,000 years ago, on a day with weather much like today's, a prehistoric person tread high up in what is now the Swiss Alps, wearing goat leather pants, leather shoes and armed with a bow and arrows.
The unremarkable journey through the Schnidejoch pass, a lofty trail 2,756 metres (9,000 feet) above sea level, has been a boon to scientists. But it would never have emerged if climate change were not melting the nearby glacier.
So far, 300 objects dating as far back as the Neolithic or New Stone Age -- about 4,000 BC in Europe -- to the later Bronze and Iron Ages and the Medieval era have been found in the site's former icefields.
"We know now that the discoveries on Schnidejoch are the oldest of this kind ever made in the Alps," said Albert Hafner, an expert with the archaeology service in Bern canton.
They have allowed researchers not only to piece together snapshots of life way back when, but also to shed light on climate fluctuations in the past 6,500 years -- and hopefully shed light on what is happening now.
"For us, the site itself is the most important find because we have this correlation between climate change and archaeological objects," Hafner said.
"We know that people were only able to walk on this site when it was relatively warm," said Martin Grosjean, executive director of a national network called Swiss Climate Research. "When it was too cold, the glacier advanced and it was not a passable route."
Scientists have long known there were periods of warmer weather in the region but the artefacts allowed them to identify the exact years, when the site would have been passable on foot.
According to Grosjean, such data could help sharpen forecasts for the future by taking into account patterns of natural temperature fluctuation.
The treasure trove preserved in the icefields was discovered after two hikers noticed a strange piece of wood lying upon some stones in 2003.
It turned out to be a quiver -- a case for arrows -- made from birch bark and dating as far back as 3,000 B.C. Hafner said this object may be the most significant single discovery at the site.
"It is the only quiver found that is made of birch bark. It is unique in Europe," he said.
Since then, even older objects have been excavated, including a wooden bow estimated to predate by 1,000 years the famed "Oetzi the Iceman" -- a 5,100-year-old frozen body found high in the Tyrolean Alps on a glacier straddling Italy and Austria in 1991.
Experts have deduced that many of the most valuable items may have originated from one ill-fated person, probably carrying the quiver, bow and arrows and clothed in leather pants and shoes.
"We think the person may have been killed during an accident because there were several objects from the same period found on the site," said Hafner. "It is unlikely that people would be leaving these objects so high up in the mountain."
The leather samples are also the oldest of their kind ever found, said Grosjean. "Leather decays easily in ambient temperatures. We know there were villages by the lakes in Switzerland but we've never found such leather objects," he said.
Analysis showed the pants' patch was made from a domesticated goat that resembled a breed recorded in Laos in those days.
"But the chances that the goat migrated from Laos are very slim. It could be a species that we had never before recorded to have been present in the Europe. Or its lineage may have died out since," said Grosjean.
Five years on, discoveries continue as the glaciers retreats.
"Last week, we found another Roman coin," said Grosjean, while Hafner said talks were underway with several museums on a future exhibition of the finds.
And with climate change, more such sites could emerge.
"The leather pieces are the oldest such finds now but maybe in the coming years, with other glaciers retreating around the world, they may not be the oldest for long," said Grosjean.
A recent UN Environment Programme report said by the end of the century, swathes of mountain ranges worldwide risk losing their glaciers if global warming continues at its projected rate.
"The ongoing trend of worldwide and rapid, if not accelerating, glacier shrinkage ... may lead to the deglaciation of large parts of many mountain ranges by the end of the 21st century," the report warned.
Article: HERE
A green woodhoopoe. Rival groups of birds behave like football fans, shouting chants at each other and commiserating with each other after a loss, research from Bristol University has revealed.
(AFP/Bristol University/Claire Spottiswoode)By LAURAN NEERGAARD, AP Medical Writer
Thu Sep 4, 9:21 pm ET
Gene domino effect behind brain, pancreatic tumors
WASHINGTON – Scientists have mapped the cascade of genetic changes that turn normal cells in the brain and pancreas into two of the most lethal cancers. The result points to a new approach for fighting tumors and maybe even catching them sooner. Genes blamed for one person's brain tumor were different from the culprits for the next patient, making the puzzle of cancer genetics even more complicated.
But Friday's research also found that clusters of seemingly disparate genes all work along the same pathways. So instead of today's hunt for drugs that target a single gene, the idea is to target entire pathways that most patients share. Think of delivering the mail to a single box at the end of the cul-de-sac instead of at every doorstep.
The three studies, published in the journals Science and Nature, mark a milestone in cancer genetics.
"This is the next wave," said Dr. Phillip Febbo of Duke University's Institute for Genome Sciences and Policy, who was not involved with the new research. "What's really important is that finding those common elements within the landscape suggests there are therapeutic interventions that can help the whole group."
Despite 30 years of laborious work, scientists until now have found only a fraction of the genetic alterations required to cause any of the 200 diseases that collectively are called cancer. Different tumors require a different domino effect of genetic changes to arise, and to determine their severity and even which treatments will work.
The new maps do not include just mutated genes. They cite missing ones, extra ones, and overactive or underactive ones, too, in the most comprehensive look ever at human tumors.
Teams led by Johns Hopkins University examined more than 20,000 genes in tumors taken from 24 pancreatic cancer patients and 22 patients with the most dangerous brain tumor, called glioblastoma multiforme. Separately, The Cancer Genome Atlas project — a government-funded network of 18 medical centers — analyzed 600 genes in glioblastomas from 206 patients.
The Hopkins teams found hundreds of genetic changes, including a particularly intriguing gene named IDH1. Twelve percent of glioblastoma patients, mostly young ones, harbored a mutated version that brought longer survival: a median of 3.8 years compared with the 1.1 years for patients without the mutation.
If additional study proves that effect, doctors soon might use an IDH1 test to help determine prognosis, said Hopkins' Dr. Victor Velculescu, who led the glioblastoma work. If so, the next question is whether certain drugs work better in those patients as well.
The bigger discovery involved cancer's genetic chaos. No tumors were identical. The typical pancreatic cancer contained 63 genetic alterations and the average brain tumor 60, Hopkins researchers reported in Science.
Fortunately, "genes don't work alone," said Hopkin's Dr. Kenneth Kinzler, who led the pancreatic work. Figure out which genes cluster in which pathways and "a simpler picture emerges."
The Hopkins team identified 12 core pathways that were abnormal in most pancreatic tumors. In Nature, The Cancer Genome Atlas researchers reported three core pathways at work in most glioblastomas.
The pathways do different things. Some allow damaged DNA to escape repair. Some switched off protective factors meant to suppress tumors.
Finding drugs that block those pathways will not be easy, said Dr. Bert Vogelstein of Hopkins and the Howard Hughes Medical Institute, who oversaw the research. They also may cause more side effects than current "targeted therapies" that work against only a specific gene defect.
But companies already are researching drugs to block a particular enzyme pathway implicated in the studies.
Also, pathway blockers should work in larger groups of patients, Vogelstein said. One particular pancreatic cancer pathway contains a variety of genes mutated in only a few people, but regardless of which gene ran amok, the whole pathway was broken in every tumor studied. "Even though it sounds complex, it's actually allowing us to simplify the complex into pathways that will allow us, I think, to truly understand cancer for the first time and take a much more rational approach to treatment," said Dr. Anna Barker of the National Cancer Institute, who co-directs the cancer atlas project. "I'm more optimistic."
Moreover, the work suggests possible ways to catch cancer earlier, by tracing mutant DNA floating through the bloodstream well before tumors themselves start to spread, Vogelstein added. "I don't think that's any longer science fiction."
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On the Net:
The Cancer Genome Atlas: http://cancergenome.nih.gov/
Article: HERE
By Luke Salkeld
Last updated at 1:08 AM on 05th September 2008
Goodbye, boys... Eva Herzigova may have to cover up as the EU pulls the plug on 'sexist' TV commercials
They have amused us, angered us and sometimes - just occasionally - they have actually made us buy something.
But now the end could be in sight for adverts which use sex to sell after they came under the unforgiving gaze of Brussels.
And, this being the EU, it is not simply raunchy advertising that is in danger. Any campaigns which are deemed sexist might have to go.
Sexist? Adverts like this Wonderbra one, famously featuring a scantily-clad Eva Herzigova, could be banned under new EU rules
That could mean an end to attractive women advertising perfume, housewives seen in the kitchen and men doing DIY.
The new rules on sexism and inequality in advertising come in a report by the EU's women's rights committee which has been adopted by the European Parliament.
It wants anything which promotes women as sex objects or reinforces gender stereotypes to be banned.
Such a move would send shockwaves through the industry.
It would probably prevent images of models